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Fungicides are among the environmental exposures that can create abnormal development for at least four generations after the exposure of the great-great-grandparent.
"Michael Skinner has just uttered an astounding sentence, but by now he is so used to slaying scientific dogma that his listener has to interrupt and ask if he realizes what he just said. Which was this: “We just published a paper last month confirming epigenetic changes in sperm which are carried forward transgenerationally. This confirms that these changes can become permanently programmed.”
OK, so it’s not bumper-sticker-ready. But if Skinner, a molecular biologist at Washington State University, were as proficient with soundbites as he is with mass spectrometry, he might have explained it this way: the life experiences of grandparents and even great-grandparents alter their eggs and sperm so indelibly that the change is passed on to their children, grandchildren, and beyond. It’s called transgenerational epigenetic inheritance: the phenomenon in which something in the environment alters the health not only of the individual exposed to it, but also of that individual’s descendants..."